The Clarke Group

Publications

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  • Currently displaying 1 - 20 of 167 publications
Author(s)
Publication title
Journal Name
Publication year
Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs**
JA Miles, F Hobor, CH Trinh, J Taylor, C Tiede, PR Rowell, BR Jackson, FA Nadat, P Ramsahye, HF Kyle, BIM Wicky, J Clarke, DC Tomlinson, AJ Wilson, TA Edwards
ChemBioChem
(2020)
22
(doi: 10.1002/cbic.202000585)
Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry.
L Staby, KR Kemplen, A Stein, M Ploug, J Clarke, K Skriver, PO Heidarsson, BB Kragelund
Cell Mol Life Sci
(2020)
78
(doi: 10.1007/s00018-020-03639-z)
The folding and unfolding behavior of ribonuclease H on the ribosome.
MK Jensen, AJ Samelson, A Steward, J Clarke, S Marqusee
J Biol Chem
(2020)
295
(doi: 10.1074/jbc.RA120.013909)
Spontaneous oligomerization of BAK/BAX is suppressed by hetero-dimerization with MCL-1
BIM Wicky, K Gupta, TOC Kwan, CV Robinson, J Clarke
(2019)
(doi: 10.1101/756874)
Extrinsic conditions influence the self-association and structure of IF1, the regulatory protein of mitochondrial ATP synthase
V Boreikaite, BIM Wicky, IN Watt, J Clarke, JE Walker
Proc Natl Acad Sci U S A
(2019)
116
(doi: 10.1073/pnas.1903535116)
Adaptation of Proteins to the Cold in Antarctic Fish: A Role for Methionine?
C Berthelot, J Clarke, T Desvignes, H William Detrich, P Flicek, LS Peck, M Peters, JH Postlethwait, MS Clark
Genome biology and evolution
(2019)
11
(doi: 10.1093/gbe/evy262)
The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome
P Tian, A Steward, R Kudva, T Su, PJ Shilling, AA Nickson, JJ Hollins, R Beckmann, G von Heijne, J Clarke, RB Best
Proc Natl Acad Sci U S A
(2018)
115
(doi: 10.1073/pnas.1810523115)
Non-Native Cooperative Interactions Modulate Protein Folding Rates
F Bruno da Silva, VG Contessoto, VM de Oliveira, J Clarke, VBP Leite
The journal of physical chemistry. B
(2018)
122
(doi: 10.1021/acs.jpcb.8b08990)
Investigating the Effect of Chain Connectivity on the Folding of a Beta-Sheet Protein On and Off the Ribosome
AP Marsden, JJ Hollins, C O'Neill, P Ryzhov, S Higson, CATF Mendonça, TO Kwan, LG Kwa, A Steward, J Clarke
J Mol Biol
(2018)
430
(doi: 10.1016/j.jmb.2018.10.011)
Promiscuous and selective: how intrinsically disordered BH3- proteins interact with their pro-survival partner MCL-1.
L Dahal, TOC Kwan, JJ Hollins, J Clarke
J Mol Biol
(2018)
430
(doi: 10.1016/j.jmb.2018.04.004)
Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins.
MD Crabtree, CATF Mendonça, QR Bubb, J Clarke
J Biol Chem
(2018)
293
(doi: 10.1074/jbc.ra118.002791)
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (vol 8, 2017)
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-03452-0)
Conservation of Folding Mechanism in Cotranslational Folding of Titin I27
P Tian, A Steward, J Clarke, RB Best
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3242)
Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex.
L Dahal, SL Shammas, J Clarke
Biophysical Journal
(2017)
113
(doi: 10.1016/j.bpj.2017.10.015)
pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.
L Dahal, TOC Kwan, SL Shammas, J Clarke
Biophys J
(2017)
113
(doi: 10.1016/j.bpj.2017.10.016)
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
Nature Communications
(2017)
8
(doi: 10.1038/s41467-017-01163-6)
Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.
BIM Wicky, SL Shammas, J Clarke
Proc Natl Acad Sci U S A
(2017)
114
(doi: 10.1073/pnas.1705105114)
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
MD Crabtree, W Borcherds, A Poosapati, SL Shammas, GW Daughdrill, J Clarke
Biochemistry
(2017)
56
(doi: 10.1021/acs.biochem.7b00179)
Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1.
W-T Chu, J Clarke, SL Shammas, J Wang
PLoS computational biology
(2017)
13
(doi: 10.1371/journal.pcbi.1005468)
Cotranslational folding of spectrin domains via partially structured states
OB Nilsson, AA Nickson, JJ Hollins, S Wickles, A Steward, R Beckmann, G von Heijne, J Clarke
Nature structural & molecular biology
(2017)
24
(doi: 10.1038/nsmb.3355)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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